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Closing Date: 15 February 2020
We are seeking a motivated Research fellow to join the Lako group at Biosciences Institute. The MRC funded project aims to use the patient specific PRPF8-iPSC model to understand how mutations in pre-mRNA splicing factor 8 (PRPF8) results in Retinitis Pigmentosa (RP). This work follows us from our work on PRPF31-RP (PMID: 30315276). The project is a collaboration between Lako’s group at with four other groups located at the University of Leeds, University of Durham, UCL London and Max Planck Institute in Gottingen. A scientific background on pluripotent stem cell differentiation and retinal biology will be essential and applicants with record of accomplishment and expertise in eye and retinal development are preferred.
This post is available from 1 April 2020, tenable for 36 months. Informal enquiries can contact Professor Linda Lako ([email protected])
As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Although working under the general guidance of an academic or Principal Investigator, they will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial ‘added value’
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding
Start to develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
Perform the differentiation of human pluripotent stem cells to kidney and retinal organoids
Carry out the characterisation of organoids and cilia length and frequency measurements
Be involved in the bioinformatic analysis of differentially spliced transcripts and differentially expressed proteins between patient organoids and isogeneic controls
Validate the results of transcriptomic and proteomic analysis
Use splice-switching morpholino oligonucleotides to validate the candidate mis-spliced transcripts in retinal and kidney cells
Regular liaison with the Principal Investigator, researchers working on retinal and stem cell differentiation team and collaborators to ensure high quality of research and timely delivery of the project goals
Perform data extraction and analysis and ensure full compliance with existing ethical regulations as appropriate
Lead on the production of high level scientific information including analysing, writing and presenting reports and manuscripts relevant to the transplantation work
Continuously review the literature and technology relevant to the project and ensure that the outputs of the project are positioned appropriately in relation to other on-going work.
Supervise BSc, MRes and BSc project students
The Person (Essential)
Knowledge, Skills and Experience
Knowledge of retinal development
Experience in generation of kidney and retinal organoids from pluripotent stem cells
Experience in kidney and retinal tissue processing and immunohistochemistry or RNA-Scope
Experience in splicing field and application to inherited retinal disease
Knowledge of splice-switching morpholino oligonucleotides in retinal cells
Evidence of a record of research including publication and presentation of data at conferences
Experience in generation of kidney organoids
Attributes and Behaviour
High level laboratory skills
Attention to detail
Quick to learn new skills
IT literate and competent
Able to analyse and interpret data
Strong critical thinking skills
Evidence of good oral communication skills; flexible independent working; initiative; and ability to work as part of a multi-disciplinary team
Excellent interpersonal skills
Able to prioritise key task and meet deadlines
Willingness to work outside normal hours and weekends as necessary
Highly motivated and enthusiastic
Experience of supervision of junior staff members
Experience of managing/organising lab
Bachelor’s degree (or equivalent) in a science, medicine or health-related subject and
A PhD or the equivalent in professional qualifications and experience in the research area required (or close to submission of PhD for Research Assistant level)
is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.
Requisition ID: 2301
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